The role of allergy in the pathogenesis of purpura and thrombocytopenia.

Can Macrothrombocytopenia Mislead the Treatment of Idiopathic Thrombocytopenia Purpura?

Idiopathic thrombocytopenia purpura (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia and mucocutaneous bleeding. The former has a primary role in the diagnosis and treatment of ITP. One of the leading causes of miscounted platelets in patients who suffer from ITP is giant platelets which may indicate factitiously a severe false thrombocytopenia. Here, a case of macroth...

Disseminated Intravascular Coagulation in a Case of Brucellosis Misdiagnosed as Thrombotic Thrombocytopenia Purpura

Role of IgE Low-Affinity Receptor (CD23) in Pathogenesis of Nasal Polyp

Background: Nasal polyps, a common clinical problem, are characterized by eosinophilic and mast cell inflammation.  The role of allergy and IgE in pathogenesis of nasal polyps is still unclear.  IgE receptors are important components of the immunological pathway in allergic and inflammatory diseases. Objective: To determine if the low affinity IgE receptor (CD23) is presented on nasal polyp tis...

Recovery of Thrombocytopenia after Eradica-tion of H. pylori Infection in Chronic Idiopathic Thrombocytopenic Purpura

Introduction: Recent studies have shown a relationship between H. pylori and chronic idiopathic thrombocytopenic purpura (CITP). Objective: The present study was performed to evaluate this relationship in Iranian patients. Methods:  The antibody (IgG) against H. pylori was studied in sixty-two patients with CITP, comprising 25 males and  37 females (mean age: 30.38±12.23 yrs ) The patients posi...

Large Ovarian Hemorrhagic Cyst and Immune Thrombocytopenia as Early Manifestations of Systemic Lupus Erythematosus (SLE)

Hematologic abnormali"es are generally present among systemic lupus erythematosus pa"ents. Idiopathic thrombocytopenic purpura can be the first manifesta"on of SLE, followed by other symptoms and signs of disease appearing several years later. Although bleeding due to immune thrombocytopenic purpura is usually mild and occurs in mucocutaneous surfaces, but it may be severe and represent in u...